​​
Magrané Laboratory

Of the Feil Family  Brain and Mind Research Institute
at ​​Weill Cornell Medical College​​

Our Research

  1. Giussepe Yanez at the Confocal Microscope
  2. Giussepe Yanez and Dr. Cristina María Lao Peregrin at the lab
  3. Dr. Jordi Magrané and Dr. Rebeca Valero Gils in the Confocal Microscope Room
  4. Dr. Jordi Magrané and Dr. Rebeca Valero Gils in the Confocal Microscope Room
  5. Dr. Jordi Magrané and Dr. Rebeca Valero Gils in the Confocal Microscope Room
  6. Giussepe Yanez at the Thermocycler (PCR) Machine
  7. Dr. Rebeca Valero Gils Preparing Agarose Gel
  8. Dr. Rebeca Valero Gils Running a PCR
  9. Giussepe Yanez Loading Samples for the PCR
  10. Giussepe Yanez Loading Samples for the PCR
  11. Giussepe Yanez Coating Plates with Media
  12. Niharika Desiraju Cutting Brain Samples with the Vibratome
  13. Niharika Desiraju Cutting Brain Samples with the Vibratome
  14. Giussepe Yanez Working on a PCR
  15. Lab Meeting Presentation by Dr. Cristina María Lao Peregrin
  16. Managing Director
Current research aims to understand how changes in the dynamics and distribution of mitochondria contribute to synaptic dysfunction and axonal neurodegeneration in neurodegenerative diseases. We are developing microscopy-based, live imaging assays to assess the role of mitochondria in the pathogenesis of Friedreich's Ataxia (FA). The ability to image mitochondria in a mouse overcomes the limitations that the use of isolated neurons displays and allows for the correlation of mitochondrial transport and distribution abnormalities with disease progression in longitudinal studies. We use pharmacological and genetic approaches in isolated sensory neurons as well as in vivo models of FA with the purpose of dissecting molecular mechanisms of sensory loss, and evaluating therapeutic strategies that prevent or reverse FA phenotypes. For the past few years, our research has focused on studying abnormalities in the axonal dynamics of mitochondria (transport, fusion, and fission), an emerging topic in the overall field of neurodegenerative diseases. In the future, we plan on combining these live imaging assays with molecular approaches in order to identify the mechanisms that cause axonal transport abnormalities in certain neurodegenerative diseases and to investigate the spatial and temporal relationship between mitochondria and synaptic plasticity.

Click here to access our Publications, and here to meet the Principal Investigator and his team.